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KMID : 0381020070400080708
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Korean Journal of Nutrition
2007 Volume.40 No. 8 p.708 ~ p.718
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The Effect of Alpha-tocopherol Supplementation on the Improvement of Antioxidant Status and Lymphocyte DNA Damage in Postmenopausal Women
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Kim Chang-Suk
Kang Hae-Jin
Lee Soon-Hee
Park Yoo-Kyoung
Kang Myung-Hee
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Abstract
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The purpose of this project was to evaluate whether vitamin E supplementation could improve the antioxidant status and lymphocyte DNA damage in Korean postmenopausal women. This was double blinded, placebo-controlled trial. Thirty-five subject were randomized to receive either placebo 400 mg/capsule or natural -tocopherol 400 IU/capsule, 2 times a day for 6 weeks. We measured plasma vitamin C, -tocopherol, -tocopherol, -carotenoid, -carotenoid, lycopene concentration and tail length, %DNA in tail, tail moment in lymphocyte DNA damage index. Vitamin E supplementation group had significantly increased plasma vitamin C(p<0.05), -tocopherol(p<0.000), whereas -tocopherol(p<0.000) and tail length(p<0.05) were significantly decreased. However, placebo supplementation group also had significantly increased plasma vitamin C(p<0.05). In conclusion, our study shows that vitamin E supplementation to Korean postmenopausal women may partially improve antioxidant status and lymphocyte DNA damage.
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KEYWORD
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vitamin E supplementation, antioxidant status, lymphocyte DNA damage, postmenopausal
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